Publications

Kinase Inhibition by PKC412 Prevents Epithelial Sheet Damage in Autosomal Dominant Epidermolysis Bullosa Simplex through Keratin and Cell Contact Stabilization. Rietscher K, Jahnke HG, Rübsam M, Lin EW, Has C, Omary MB, Niessen CM, Magin TM.  J Invest Dermatol. 2022 Jun 9:S0022-202X(22)01531-7. doi: 10.1016/j.jid.2022.05.1088. Epub ahead of print. PMID: 35691363.

The Desmosome-Keratin Scaffold Integrates ErbB Family and Mechanical Signaling to Polarize Epidermal Structure and Function. Green KJ, Niessen CM, Rübsam M, Perez White BE, Broussard JA. Front Cell Dev Biol. 2022 May 24;10:903696. doi: 10.3389/fcell.2022.903696. PMID: 35686051; PMCID: PMC9171019.

How to Build and Regenerate a Functional Skin Barrier: The Adhesive and Cell Shaping Travels of a Keratinocyte. Peskoller M, Bhosale A, Göbel K, Löhr J, Miceli S, Perot S, Persa O, Rübsam M, Shah J, Zhang H, Niessen CM. J Invest Dermatol. 2022 Apr;142(4):1020-1025. doi: 10.1016/j.jid.2021.12.034. Epub 2022 Jan 17. PMID: 35051379.

Scaffold polarity proteins Par3A and Par3B share redundant functions while Par3B acts independent of atypical protein kinase C/Par6 in podocytes to maintain the kidney filtration barrier.  Koehler S, Odenthal J, Ludwig V, Unnersjö Jess D, Höhne M, Jüngst C, Grawe F, Helmstädter M, Janku JL, Bergmann C, Hoyer PF, Hagmann HH, Walz G, Bloch W, Niessen C, Schermer B, Wodarz A, Denholm B, Benzing T, Iden S, Brinkkoetter PT. Kidney Int. 2022 Apr;101(4):733-751. doi: 10.1016/j.kint.2021.11.030. Epub 2021 Dec 17. PMID: 34929254.

Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility. Koester J, Miroshnikova YA, Ghatak S, Chacón-Martínez CA, Morgner J, Li X, Atanassov I, Altmüller J, Birk DE, Koch M, Bloch W, Bartusel M, Niessen CM, Rada-Iglesias A, Wickström SA. Nat Cell Biol. 2021 Jul;23(7):771-781. doi: 10.1038/s41556-021-00705-x. Epub 2021 Jul 8. PMID: 34239060.

Laminin 332 Is Indispensable for Homeostatic Epidermal Differentiation Programs. Tayem R, Niemann C, Pesch M, Morgner J, Niessen CM, Wickström SA, Aumailley M. J Invest Dermatol. 2021 May 7:S0022-202X(21)01215-X. doi: 10.1016/j.jid.2021.04.008. Epub ahead of print.

Regulation of Cell Polarity and Tissue Architecture in Epidermal Aging and Cancer. Persa OD, Koester J, Niessen CM. J Invest Dermatol. 2021 Apr;141(4S):1017-1023. doi: 10.1016/j.jid.2020.12.012.

Mechanochemical control of epidermal stem cell divisions by B-plexins. Jiang C, Javed A, Kaiser L, Nava MM, Xu R, Brandt DT, Zhao D, Mayer B, Fernández-Baldovinos J, Zhou L, Höß C, Sawmynaden K, Oleksy A, Matthews D, Weinstein LS, Hahn H, Gröne HJ, Graumann PL, Niessen CM, Offermanns S, Wickström SA, Worzfeld T.Nat Commun. 2021 Feb 26;12(1):1308. doi: 10.1038/s41467-021-21513-9. PMID: 33637728

Stretch exercises for stem cells expand the skin. Rübsam M, Niessen CM. Nature. 2020 Aug 584(7820): 196-198. doi: 10.1038/d41586-020-02158-y.

Heterochromatin-Driven Nuclear Softening Protectsthe Genome against Mechanical-Stress-Induced Damage.Nava MM, Miroshnikova YA, Biggs LC, Whitefield DB, Metge F, Boucas J, Vihinen H, Jokitalo E, Li X, García Arcos YN, Hoffmann B, Merkel R, Niessen CM, Dahl KN, and Wickström SA. Cell. 2020 Apr 9. 181, 1–18. DOI: 10.1016/j.cell.2020.03.052

Tracing the Evolutionary Origin of Desmosomes. Green KJ, Roth-Carter Q, Niessen CM, Nichols SA. Curr Biol. 2020 May 18;30(10):R535-R543. doi: 10.1016/j.cub.2020.03.047. PMID: 32428495; PMCID: PMC7310670.

Emerging mechanisms driving cell differentiation in vivo. Niessen CM, Plachta NA. Curr Opin Cell Biol. 2020 Dec;67:iii-v. doi: 10.1016/j.ceb.2020.10.003. Epub 2020 Nov 10. PMID: 33187809.

Murine Epidermal Ceramide Synthase 4 is a Key Regulator of Skin Barrier Homeostasis. Peters F, Tellkamp F, Brodesser S, Wachsmuth E, Tosetti B, Karow U, Bloch W, Utermöhlen O, Krönke M, Niessen CM. J Invest Dermatol. 2020 Feb 22. DOI:10.1016/j.jid.2020.02.006. PMID: 32092351

Identification of host trafficking genes required for HIV-1 virological synapse formation in dendritic cells. Bayliss R, Wheeldon J, Caucheteux SM, Niessen CM, Piguet VJ. Virol. 2020 Feb 19.DOI: 10.1128/JVI.01597-19. PMID: 32075937

Small-scale demixing in confluent biological tissues. Sahu P, Sussman DM, Rübsam M, Mertz AF, Horsley V, Dufresne E.R, Niessen CM, Marchetti MC, Manning ML, Schwarz JM.Soft Matter. 2020 Apr 1;16(13):3325-3337. DOI: 10.1039/c9sm01084j. PMID: 32196025

Intrauterine growth restriction induces skin inflammation, increases TSLP and impairs epidermal barrier function. Polányi L, Niessen CM, Vohlen C, Stinn J, Kretschmer T, Jentgen V, Hirani D, Koningsbruggen-Rietschel SV, Dötsch J, Alejandre Alcazar MA. J Mol Med (Berl). 2020 Feb;98(2):279-289. DOI: 10.1007/s00109-019-01867-w. PMID: 31912169

Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis.Clayton RW, Göbel K, Niessen CM, Paus R, van Steensel MAM, Lim X. Br J Dermatol. 2019 May 6. doi: 10.1111/bjd.17981. [Epub ahead of print] Review. PMID: 31056753

Epithelial polarity limits EMT. Persa OD, Niessen CM. Nat Cell Biol. 2019 Mar;21(3):299-300. doi: 10.1038/s41556-019-0284-7. No abstract available. PMID: 30824839

Hepatitis B virus promotes β-catenin-signalling and disassembly of adherens junctions in a Src kinase dependent fashion. von Olshausen G, Quasdorff M, Bester R, Arzberger S, Ko C, van de Klundert M, Zhang K, Odenthal M, Ringelhan M, Niessen CM, Protzer U. Oncotarget. 2018 Sep 21;9(74):33947-33960. doi: 10.18632/oncotarget.26103. eCollection 2018 Sep 21.

Transition of responsive mechanosensitive elements from focal adhesions to adherens junctions upon epithelial differentiation. Noethel B, Ramms L, Dreissen G, Hoffmann M, Springer R, Rübsam M, Ziegler WH, Niessen CM, Merkel R, Hoffmann B. Mol Biol Cell. 2018 Jul 25:mbcE17060387. doi: 10.1091/mbc.E17-06-0387. [Epub ahead of print] PMID: 30044710

E-cadherin binds to desmoglein to facilitate desmosome assembly. Shafraz O, Rübsam M, Stahley SN, Caldara A, Kowalczyk AP, Niessen CM, Sivasankar S. Elife. 2018 Jul 12;7. pii: e37629. doi: 10.7554/eLife.37629. [Epub ahead of print] PMID: 29999492

Cell adhesion and mechanics as drivers of tissue organization and differentiation: local cues for large scale organization. Wickström SA, Niessen CM. Curr Opin Cell Biol. 2018 Jun 1;54:89-97. doi: 10.1016/j.ceb.2018.05.003. [Epub ahead of print] Review. PMID: 29864721

Shared and independent functions of aPKCλ and Par3 in skin tumorigenesis. Vorhagen S, Kleefisch D, Persa OD, Graband A, Schwickert A, Saynisch M, Leitges M, Niessen CM, Iden S. Oncogene. 2018 May 23. doi: 10.1038/s41388-018-0313-1. PMID: 29789715

AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer. Welcker D, Jain M, Khurshid S, Jokić M, Höhne M, Schmitt A, Frommolt P, Niessen CM, Spiro J, Persigehl T, Wittersheim M, Büttner R, Fanciulli M, Schermer B, Reinhardt HC, Benzing T, Höpker K. Oncogene. 2018 Jan 11. doi: 10.1038/s41388-017-0054-6. PMID: 29321668

Keratinocyte-specific ablation of RIPK4 allows epidermal cornification but impairs skin barrier formation. Urwyler-Rösselet C, Tanghe G, Leurs K, Gilbert B, De Rycke R, De Bruyne M, Lippens S, Bartunkova S, De Groote P, Niessen C, Haftek M, Vandenabeele P, Declercq W. J Invest Dermatol. 2018 Jan 6. pii: S0022-202X(18)30006-X. doi: 10.1016/j.jid.2017.12.031. PMID: 29317263

Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification. Miroshnikova YA, Le HQ, Schneider D, Thalheim T, Rübsam M, Bremicker N, Polleux J, Kamprad N, Tarantola M, Wang I, Balland M, Niessen CM, Galle J, Wickström SA. Nat Cell Biol. 2018 Jan;20(1):69-80. doi: 10.1038/s41556-017-0005-z. Epub 2017 Dec 11. PMID: 29230016

E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning. Rübsam M, Mertz AF, Kubo A, Marg S, Jüngst C, Goranci-Buzhala G, Schauss AC, Horsley V, Dufresne ER, Moser M, Ziegler W, Amagai M, Wickström SA, Niessen CM. Nat Commun. 2017 Nov 1;8(1):1250. doi: 10.1038/s41467-017-01170-7. PMID: 29093447

Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary Perspective. Rübsam M, Broussard JA, Wickström SA, Nekrasova O, Green KJ, Niessen CM. Cold Spring Harb Perspect Biol. 2017 Sep 11. pii: a029207. doi: 10.1101/cshperspect.a029207. PMID: 28893859

Imbalance of Mitochondrial Respiratory Chain Complexes in the Epidermis Induces Severe Skin Inflammation. Weiland D, Brachvogel B, Hornig-Do HT, Neuhaus JFG, Holzer T, Tobin DJ, Niessen CM, Wiesner RJ, Baris OR. J Invest Dermatol. 2018 Jan;138(1):132-140. doi: 10.1016/j.jid.2017.08.019. Epub 2017 Sep 1. PMID: 28867657

The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma. Mescher M, Jeong P, Knapp SK, Rübsam M, Saynisch M, Kranen M, Landsberg J, Schlaak M, Mauch C, Tüting T, Niessen CM, Iden S. J Exp Med. 2017 Feb;214(2):339-358. doi: 10.1084/jem.20160596. Epub 2017 Jan 17. PMID: 28096290

Epithelial Barriers in Murine Skin during Herpes Simplex Virus 1 Infection: The Role of Tight Junction Formation. Rahn E, Thier K, Petermann P, Rübsam M, Staeheli P, Iden S, Niessen CM, Knebel-Mörsdorf D. J Invest Dermatol. 2017 Apr;137(4):884-893. doi: 10.1016/j.jid.2016.11.027. Epub 2016 Dec 6. PMID: 27939379

The Mitochondrial m-AAA Protease Prevents Demyelination and Hair Greying. Wang S, Jacquemyn J, Murru S, Martinelli P, Barth E, Langer T, Niessen CM, Rugarli EI. PLoS Genet. 2016 Dec 2;12(12):e1006463. doi: 10.1371/journal.pgen.1006463. eCollection 2016 Dec. PMID: 27911893

Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment. Le HQ, Ghatak S, Yeung CY, Tellkamp F, Günschmann C, Dieterich C, Yeroslaviz A, Habermann B, Pombo A, Niessen CM, Wickström SA. Nat Cell Biol. 2016 Aug;18(8):864-75. doi: 10.1038/ncb3387. Epub 2016 Jul 11. PMID: 27398909

Degrees of Freedom: Your Future in Biomedical Research. Green KJ, Niessen CM. J Invest Dermatol. 2016 Jun;136(6):1073-6. doi: 10.1016/j.jid.2016.03.025. No abstract available. PMID: 27212644

Par3A is dispensable for the function of the glomerular filtration barrier of the kidney. Koehler S, Tellkamp F, Niessen CM, Bloch W, Kerjaschki D, Schermer B, Benzing T, Brinkkoetter PT. Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F112-9. doi: 10.1152/ajprenal.00171.2016. Epub 2016 Apr 27. PMID: 27122542

Growth Retardation, Loss of Desmosomal Adhesion, and Impaired Tight Junction Function Identify a Unique Role of Plakophilin 1 In Vivo. Rietscher K, Wolf A, Hause G, Rother A, Keil R, Magin TM, Glass M, Niessen CM, Hatzfeld M. J Invest Dermatol. 2016 Jul;136(7):1471-1478. doi: 10.1016/j.jid.2016.03.021. Epub 2016 Mar 28. PMID: 27033150

Myeloid Cell-Restricted Insulin/IGF-1 Receptor Deficiency Protects against Skin Inflammation. Knuever J, Willenborg S, Ding X, Akyüz MD, Partridge L, Niessen CM, Brüning JC, Eming SA. J Immunol. 2015 Dec 1;195(11):5296-5308. doi: 10.4049/jimmunol.1501237. Epub 2015 Oct 30. PMID: 26519530

Ceramide synthase 4 regulates stem cell homeostasis and hair follicle cycling. Peters F, Vorhagen S, Brodesser S, Jakobshagen K, Brüning JC, Niessen CM, Krönke M.J Invest Dermatol. 2015 Jun;135(6):1501-9. doi: 10.1038/jid.2015.60. Epub 2015 Feb 23. PMID: 25705848

Epidermal polarity genes in health and disease. Tellkamp F, Vorhagen S, Niessen CM. Cold Spring Harb Perspect Med. 2014 Dec 1;4(12):a015255. doi: 10.1101/cshperspect.a015255. PMID: 25452423

Mammalian aPKC/Par polarity complex mediated regulation of epithelial division orientation and cell fate.Vorhagen S, Niessen CM. Exp Cell Res. 2014 Aug 13. pii: S0014-4827(14)00336-X. doi: 10.1016/j.yexcr.2014.08.008. Review.

Tropism-modified AAV vectors overcome barriers to successful cutaneous therapy. Sallach J, Di Pasquale G, Larcher F, Niehoff N, Rübsam M, Huber A, Chiorini J, Almarza D, Eming SA, Ulus H, Nishimura S, Hacker UT, Hallek M, Niessen CM, Büning H. Mol Ther. 2014 May;22(5):929-39. doi: 10.1038/mt.2014.14. Epub 2014 Jan 28. PMID: 24468915

Clinician scientists and PhDs: the need to connect basic research to translational medicine-a personal experience. Niessen CM, Krieg T.J Invest Dermatol. 2014 Feb;134(2):295-8. doi: 10.1038/jid.2013.466. No abstract available. PMID: 24424447

aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation. Niessen MT, Scott J, Zielinski JG, Vorhagen S, Sotiropoulou PA, Blanpain C, Leitges M, Niessen CM. J Cell Biol. 2013 Sep 16;202(6):887-900. PMID: 24019538

Insulin/IGF-1 Controls Epidermal Morphogenesis via Regulation of FoxO-Mediated p63 Inhibition. Günschmann C, Stachelscheid H, Akyüz MD, Schmitz A, Missero C, Brüning JC, Niessen CM. Dev Cell. 2013 Jul 29;26(2):176-87. PMID:23906066

Analysis of bulge stem cells from the epidermis using flow cytometry. Villani RM, Akyuz MD, Niessen MT, Niessen CM. Methods Mol Biol. 2013;989:33-43. PMID:23483385

Montagna Symposium 2012: Keeping it all together–adhesion, the cytoskeleton, and signaling in morphogenesis and tissue function. Green KJ, Niessen CM, Godsel LM, Kulesz-Martin MF.J Invest Dermatol. 2013 May;133(5):1124-8. PMID: 23594531

Cadherin-based intercellular adhesions organize epithelial cell-matrix traction forces. Mertz AF, Che Y, Banerjee S, Goldstein JM, Rosowski KA, Revilla SF, Niessen CM, Marchetti MC, Dufresne ER, Horsley V.Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):842-7. PMID:23277553

The in vivo function of mammalian cell and tissue polarity regulators–how to shape and maintain the epidermal barrier. Niessen MT, Iden S, Niessen CM. J Cell Sci. 2012 Aug 1;125(Pt 15):3501-10. PMID: 22935653

Experimental analysis of risk factors for ulcerative dermatitis in mice. Neuhaus B, Niessen CM, Mesaros A, Withers DJ, Krieg T, Partridge L.Exp Dermatol. 2012 Sep;21(9):712-3. doi: 10.1111/j.1600-0625.2012.01558. PMID: 22897579

Classical and desmosomal cadherins at a glance. Saito M, Tucker DK, Kohlhorst D, Niessen CM, Kowalczyk AP.J Cell Sci. 2012 Jun 1;125(Pt 11):2547-52. PMID: 22833291

Adherens junctions in Mammalian development, homeostasis and disease: lessons from mice. Boggetti B, Niessen CM. Subcell Biochem. 2012;60:321-55. PMID: 22674078

Vascular endothelial insulin/IGF-1 signaling controls skin wound vascularization. Aghdam SY, Eming SA, Willenborg S, Neuhaus B, Niessen CM, Partridge L, Krieg T, Bruning JC.Biochem Biophys Res Commun. 2012 May 4;421(2):197-202. PMID: 22503682

Cadherin-dependent differential cell adhesion in Xenopus causes cell sorting in vitro but not in the embryo.Ninomiya H, David R, Damm EW, Fagotto F, Niessen CM, Winklbauer R.J Cell Sci. 2012 Apr 15;125 (Pt 8):1877-83. PMID: 22328523

A function for Rac1 in the terminal differentiation and pigmentation of hair. Behrendt K, Klatte J, Pofahl R, Bloch W, Smyth N, Tscharntke M, Krieg T, Paus R, Niessen C, Niemann C, Brakebusch C, Haase I.J Cell Sci. 2012 Feb 15;125(Pt 4):896-905. PMID:22275433

TCF/Lef1-mediated control of lipid metabolism regulates skin barrier function. Fehrenschild D, Galli U, Breiden B, Bloch W, Schettina P, Brodesser S, Michels C, Günschmann C, Sandhoff K, Niessen CM, Niemann C. J Invest Dermatol. 2012 Feb;132(2):337-45. PMID: 21938009

Impaired keratinocyte proliferative and clonogenic potential in transgenic mice overexpressing 14-3-3σ in the epidermis. Cianfarani F, Bernardini S, De Luca N, Dellambra E, Tatangelo L, Tiveron C, Niessen CM, Zambruno G, Castiglia D, Odorisio T.J Invest Dermatol. 2011 Sep;131(9):1821-9. PMID: 21654836

Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation. Niessen CM, Leckband D, Yap AS.Physiol Rev. 2011 Apr;91(2):691-731. Review. PMID: 21527735

The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling. Weber S, Niessen MT, Prox J, Lüllmann-Rauch R, Schmitz A, Schwanbeck R, Blobel CP, Jorissen E, de Strooper B, Niessen CM, Saftig P.Development. 2011 Feb;138(3):495-505. PMID: 21205794