Mechanisms of ageing and cell fate
Here we aim to understand how self-renewing tissues balance proliferation and differentiation to maintain tissue homeostasis. One mechanism used to maintain this balance is oriented cell division. The decision to divide symmetrically versus asymmetrically is thought to occur by coupling spindle orientation to the equal or unequal distribution of fate determinants and/or positioning within the tissue. Therefore, this project investigates spatiotemporal dynamics of the spindle orientation machinery in mitosis.